Research

Radiation Oncology and Heavy Ion Medicine

Outline

In addition of treating more than 1000 cancer patients a year with radiation therapy, the department of radiation oncology and Heavy Ion Medical Center also deligently teach students of the Faculty of Medicine and Graduate School of Medicine and promote various researches in basic, translational and clinical medicine, including external radiation therapy, stereotactic therapy, brachytherapy, heavy ion therapy and multidisciplinary therapy for raising future multitask radiotherapists . The peaceful use of radiation is extremely important in the world. The department of radiation oncology and Heavy Ion Medical Center
collaborates with domestic and overseas leading institutions such as Mass General Hospital, GSI, Mayo clinic. It also collaborates the International Atomic Energy Agency (IAEA), in contributing to promote and raise awareness of radiation therapy and heavy ion radiotherapy in Asian region and worldwide.

Members

Title Name Specialty
Professor Takashi Nakano, M.D., Ph.D. Radiation Oncology/Heavy Ion Radiotherapy
Tatsuya Ohno, M.D., Ph.D. Radiation Oncology/Heavy Ion Radiotherapy
Associate
Professor
Jun-ichi Saitoh, M.D., Ph.D. Radiation Oncology/Heavy Ion Radiotherapy
Shin-ei Noda, M.D., Ph.D. Radiation Oncology/Heavy Ion Radiotherapy
Katsuyuki Shirai, M.D., Ph.D. Radiation Oncology/Heavy Ion Radiotherapy
Assistant
Professor
Hiroki Kiyohara, M.D., Ph.D. Radiation Oncology/Heavy Ion Radiotherapy
Hiroyuki Katoh, M.D., Ph.D. Radiation Oncology/Heavy Ion Radiotherapy
Kei Shibuya, M.D., Ph.D. Radiology/Heavy Ion Radiotherapy
Kazutoshi Murata, M.D., Ph.D. Radiation Oncology/Heavy Ion Radiotherapy
Takahiro Oike, M.D., Ph.D. Radiation Oncology/Heavy Ion Radiotherapy

Research

Clinical research

1) Research on the safety and effectiveness of carbon ion therapy (prostate cancer, liver cancer etc.)
2) Development of new brachytherapy technique for uterine cancer
3) Research on normal cells and tissue reactions after radiation therapy
(bone density measurement etc.)

 

Basic research

We are promoting following things.
1) Research into the cancer related genes, proteins and signaling pathway involved in radiosensitivity
2) Research on antitumor immunity induced by radiation therapy or hyperthermia
3) Research on the sensitizing effects of carbon ion beams
4) Research on the heavy-ion microsurgery
5) Development of medical compton camera and methods in nuclear medicine

Faculty of Medicine education

Undergraduate students study radiobiology and radiation oncology through lectures and training to acquire the basic knowledge of radiology required of a physician.

Graduate education

We offer education in a wide range of fields related to oncology, such as pathology and molecular biology with a focus on radiobiology and radiation oncology, to foster researchers and specialists in the field of radiation oncology. In particular, we pursue advanced research in heavy ion radiotherapy.

Clinical practice work

1) Radiation therapy: We provide conventional radiation therapy to over 1000 malignant tumor patients a year (brain tumor, head and neck tumors, lung cancer, breast cancer, esophageal cancer, prostate cancer, uterine cancer, malignant lymphoma etc.).(A) External irradiation with three linear accelerators(3D conformal radiation therapy, Intensity-modulated radiation therapy, stereotactic radiotherapy), (B) Image-guided adaptive brachytherapy for gynecological and prostate cancers, (C) Treatment of thyroid disease using radioactive iodine, etc.

2) Heavy ion radiotherapy: Starting in March 2010, currently we provide treatment for head and neck tumors, lung cancer, liver cancer, prostate cancer, bone and soft tissue tumors, pancreas cancer, and uterine cervical cancer with more than 20 clinical protocols.

3) Hospital care: In addition to radiation therapy, we provide chemotherapy and palliative care in the own ward.

Social contribution

1) Cooperation with the International Atomic Energy Agency (IAEA): We hold periodic educational workshops for Asian country and Prof. Nakano has served as an IAEA executive in the medical and health fields in the Asian region since 2003. Gunma University has been organizing the RCA (Regional Cooperation Agreement), in Asian country.

2) Forum for Nuclear Cooperation in Asia (FNCA):We contribute to the FNCA as a representative of Japan. In this activity, clinical trials and workshop have been carried out among Bangladesh, Indonesia, Japan, Kazakhstan, Korea, Malaysia, Mongolia, The Philippines, Thailand and Viet Nam in order to establish standardized cancer treatment with radiotherapy in Asia.

3) We work to promote heavy ion therapy and hold research meetings and lectures.

4) As the executive office for the Austral-Asian Journal of Cancer, we contribute to the development of cancer research.

5) As the executive office for the Gunma Conference for Therapeutic Radiology & Oncology, we contribute to the development of regional radiation oncology and cancer research.

Publications

A Case of Recurrent Pleomorphic Liposarcoma that Exhibited a Remarkable Response to Hyperthermoradiotherapy TAKANORI ABE, TAKESHI EBARA, KOSAKU HARADA, KATSUYUKI SHIRAI, MARIKO SHIOYA, YOSHIYUKI SUZUKI, HIDEYUKI SAKURAI, TAKASHI NAKANO Thermal Med 2013;29(3) 63-67

Particle radiotherapy with carbon ion beams Ohno Tatsuya The EPMA Journal 2013;4(1) 9

Radiotherapy concurrently with weekly cisplatin, followed by adjuvant chemotherapy, for N2-3 nasopharyngeal cancer: a multicenter trial of the Forum for Nuclear Cooperation in Asia. Ohno T, Thinh DH, Kato S, Devi CR,Tung NT, Thephamongkhol K, Calaguas MJ, Zhou J, Chansilpa Y, Supriana N, Erawati D, Banu PA, Koo CC, Kobayashi K, Nakano T, Tsujii H. J Radiat Res. 2013;54(3) 467-73

Comparison of hematological toxicities between innovator and generic cisplatin formulations in cervical cancer patients treated with concurrent chemoradiotherapy Oike T, Ohno T, Noda SE, Sato H, Tamaki T, Kiyohara H, Ando K, Nakano T J Radiat Res 2013;54(3) 474-478

Histone Acetyltransferases (HATs) Involved in Non-Homologous End Joining as a Target for Radiosensitization Takahiro Oike, Hideaki Ogiwara, Takashi Nakano and Takashi Kohno Frontiers in Radiation Oncology 2013;ISBN978-953-51-1163-4 3-12

Inactivating Mutations in SWI/SNF Chromatin Remodeling Genes in Human Cancer Oike T, Ogiwara H, Nakano T, Yokota J, Kohno T. Japanese Journal of Clinical Oncology 2013

A Synthetic Lethality-Based Strategy to Treat Cancers Harboring a Genetic Deficiency in the Chromatin Remodeling Factor BRG1 Oike T, Ogiwara H, Tominaga Y, Ito K, Ando O, Tsuta K, Mizukami T, Shimada Y, Isomura H, Komachi M, Furuta K, Watanabe S, Nakano T, Yokota J, Kohno T Cancer Res. 2013;73(17) 5508-5518

Radiotherapy plus Concomitant Adjuvant Temozolomide for Glioblastoma: Japanese Mono-Institutional Results Takahiro Oike, Yoshiyuki Suzuki, Ken-ichi Sugawara, Katsuyuki Shirai, Shin-ei Noda, Tomoaki Tamaki, Masaya Nagaishi, Hideaki Yokoo, Yoichi Nakazato, Takashi Nakano PLOS ONE 2013;8(11) e78943

Changes in Bone Mineral Density in Uterine Cervical Cancer Patients After Radiation Therapy Noriyuki Okonogi, Jun-ichi Saitoh, Yoshiyuki Suzuki, Shin-ei Noda, Tatsuya Ohno, Takahiro Oike, Yu Ohkubo, Ken Ando, Hiro Sato, and Takashi Nakano International Journal of Radiation Oncology Biology Physics 2013;87(5) 968-974

Prognosis was not deteriorated by multiple primary cancers in esophageal cancer patients treated by radiotherapy Shirai K, Tamaki Y, Kitamoto Y, Murata K, Satoh Y, Higuchi K, Ishikawa H, Nonaka T, Takahashi T,Nakano T J Radiat Re 2013

X Irradiation Changes Dendritic Spine Morphology and Density through Reduction of Cytoskeletal Proteins in Mature Neurons Katsuyuki Shirai, Toshiyuki Mizui, Yoshiyuki Suzuki, Masahiko Okamoto, Kenji Hanamura, Yukari Yoshida, Mizuki Hino, Shin-ei Noda, Wael S. Al-jahdari, Arnab Chakravarti, Tomoaki Shirao and Takashi Nakano RADIATION RESEARCH 2013;179(6) 630-6

Usefulness of double dose contrast-enhanced magnetic resonance imaging for clear delineation of gross tumor volume in stereotactic radiotherapy treatment planning of metastatic brain tumors: a dose comparison study Kalloo Sharma SUBEDI, Takeo TAKAHASHI, Takafumi YAMANO, Jun-ichi SAITOH, Keiichiro NISHIMURA, Yoshiyuki SUZUKI, Tatsuya OHNO and Takashi NAKANO Journal of Radiation Research 2013;54(1) 135-139

Three-Dimensional and Multi-Energy γ-ray Simultaneous Imaging Using a Si/CdTe Compton Camera Suzuki Y, Yamaguchi M, Odaka H, Shimada H, Yoshida Y, Torikai K, Satoh T, Arakawa K, Kawachi N, Watanabe S, Takeda S, Ishikawa SN, Aono H, Watanabe S, Takahashi T, Nakano T Radiology 2013;267(3) 941-7

Carbon-ion radiotherapy for marginal lymph node recurrences of cervical cancer after definitive radiotherapy: a case report Tomoaki Tamaki, Tatsuya Ohno, Hiroki Kiyohara, Shin-ei Noda, Yu Ohkubo, Ken Ando, Masaru Wakatsuki, Shingo Kato, Tadashi Kamada and Takashi Nakano Radiation Oncology 2013;8(1) 79-

Dose–volume histogram parameters of high-dose-rate brachytherapy for Stage I–II cervical cancer (≤4cm) arising from a small-sized uterus treated with a point A dose-reduced plan Akiko NAKAGAWA, Tatsuya OHNO, Shin-ei NODA, Nobuteru KUBO, Keiko KUWAKO, Jun-ichi SAITOH and Takashi NAKANO Journal of Radiation Research 2014

Chromatin-regulating proteins as targets for cancer therapy Takahiro OIKE, Hideaki OGIWARA, Napapat AMORNWICHET, Takashi NAKANO and Takashi KOHNO Journal of Radiation Research 2014

C646, a selective small molecule inhibitor of histone acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic catastrophe Takahiro Oike, Mayumi Komachi, Hideaki Ogiwara, Napapat Amornwichet, Yuka Saitoh, Kohta Torikai, Nobuteru Kubo, Takashi Nakano, Takashi Kohno Radiotherapy and Oncology 2014